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( a) Hydrogen-bond network around Arg249 inthe wild-type p53 DBD that maintains the structure between loops L2A and L3 (PDB: 2ocj) [ 63 ].( b) Single Arg249Ser p53 DBD mutant with the hydrogen-bond network between loops L2A andL3 broken (PDB: 3d06) [ 57 ].

Pfeffer MA McMurray JJ, Velazquez EJ, Rouleau JL, Kober L, Maggioni AP, et al.Valsartan, captopril, or both in myocardial infarction complicated by heart failure,left ventricular dysfunction or both. Thisflap can be extended as far as the umbilicus if necessary.

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In the elderly, about two-thirds of the casesare attributable to significant stenosis, ulceration, orocclusion of the ipsilateral carotid artery or occlusionof the ipsilateral common carotid artery (Parkin et al.,1982; Adams et al., 1983).

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